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Improving Cognition in Moderately Stressed Subjects

Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study

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Publication Overview

The present exploratory study was conducted to gain insight into the effect of LPHEAL9 on the gut–brain axis. Measurements of stress, cognition, mood, and sleep were investigated after intake of LPHEAL9 or placebo for 12 weeks. The primary findings in this study indicated a positive impact on cognitive performance, especially memory functions, after intake of LPHEAL9 compared to placebo. These results may be connected to the improvements over time seen by LPHEAL9 in sleep quality, overall mood, and awakening cortisol.

Publication Results

The present study was designed to evaluate the effect of the probiotic bacteria Lactiplantibacillus plantarum HEAL9 on moderately stressed but otherwise healthy individuals. Several different endpoints were included in the study, and the results showed that intake of LPHEAL9 for 12 weeks had a positive and significant impact on cognition. More specifically, the study showed a significant improvement in learning and working memory after the consumption of LPHEAL9 compared to placebo, potentially by ameliorating aspects of mood and improving sleep. These effects may be linked to the stabilization of inflammatory biomarkers and to a significantly lower awakening level of cortisol in the probiotic group compared to the baseline.

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