Publication

Effect of a Hop Extract on Bone Health and Gut Microbiome

The present clinical trial aimed to determine whether one-year consumption of a hop extract can moderate bone mineral density decreases in postmenopausal women with osteopenia.

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Publication Overview

Estrogen deficiency increases the risk of osteoporosis and fracture. The aim of this study was to investigate whether a hop extract standardized in 8-prenylnaringenin (8-PN), a potent phytoestrogen, could improve bone status of osteopenic women and to explore the gut microbiome roles in this effect. In this double-blind, placebo-controlled, randomized trial, 100 postmenopausal, osteopenic women were supplemented with calcium and vitamin D3 (CaD) tablets and either a hop extract (HE) standardized in 8-PN (n = 50) or a placebo (n = 50) for 48 weeks.

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Publication Results

An increase in the SF-36 physical functioning score was observed with HE versus placebo (p = 0.05). Gut microbiome -diversity and SCFA levels did not differ between groups. However, a higher abundance of genera Turicibacter and Shigella was observed in the HE group; both genera have been previously identified as associated with total body BMD.
These results suggest that an 8-PN standardized hop extract could beneficially impact bone health of postmenopausal women with osteopenia.

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